Liverpool travel to Germany to face Eintracht Frankfurt in a crucial Champions League fixture that could shape their European campaign. After a difficult spell, Arne Slot finds himself under pressure to restore confidence and form. His side have suffered four consecutive defeats across all competitions, including a painful home loss to Manchester United, and the Dutch manager will demand a response in Frankfurt.

Selection dilemmas for Arne Slot

Several questions surround Liverpool’s starting eleven, with changes expected in key positions. Slot is reportedly considering giving Hugo Ekitike a start against his former club. The French forward could replace Alexander Isak, who joined for £125 million but has struggled to make the desired impact. Ekitike’s energy and familiarity with Frankfurt could provide the spark Liverpool need in attack.

Florian Wirtz is another name in contention to feature prominently. The young midfielder, who has been one of the few bright spots in recent weeks, may be handed another opportunity to impress on the European stage. His creativity and composure could prove decisive against Frankfurt’s aggressive pressing style.

Injury updates and midfield balance

In midfield, Ryan Gravenberch’s is missing after he picked up an ankle issue during the defeat to Manchester United. He missed training on Tuesday, and his absence would likely see Curtis Jones step into the starting line-up. Jones’ work rate and tactical intelligence may provide the balance Liverpool have been missing.

Alexis Mac Allister has been struggling for form this season, which could see the Argentinian, rotated. Wataru Endo is listed as a doubt, adding to the manager’s selection concerns in midfield.

Defensive reshuffle and tactical shape

At the back, changes are expected. Milos Kerkez could make way for Andy Robertson, whose experience and leadership will be vital in such a high-stakes encounter. Joe Gomez is pushing to start ahead of Ibrahima Konate, as Slot seeks greater consistency in defensive transitions.

Between the posts, Giorgi Mamardashvili continues to deputise for the injured Alisson. The Georgian goalkeeper has endured mixed fortunes since stepping in, but his shot-stopping ability may prove crucial against Frankfurt’s counterattacks.

Predicted Liverpool XI

Predicted Line-Up: Mamardashvili; Frimpong, Konate, Van Dijk, Robertson; Jones, Szoboszlai; Salah, Wirtz, Gakpo; Ekitike.
Doubts: Endo
Injured: Alisson, Leoni, Gravenberch
Kick-Off: 8pm BST, Wednesday, October 22, 2025
Venue: Deutsche Bank Park, Frankfurt
How to Watch: TNT Sports